348 The relationship between clinical subtypes of pyoderma gangrenosum and neutrophil extracellular traps formation
نویسندگان
چکیده
Pyoderma gangrenosum (PG) is a chronic neutrophilic disorder characterized by recurrent painful ulcers. There are several clinical subtypes in PG: (classical) ulcerative, pustular, bullous, vegetative, and peristomal. Aseptic inflammation neutrophils plays an essential role and, neutrophil extracellular traps (NETs) formation can contribute to the lesion formation. We examined relationship between histopathological location of NETs each subtype PG specimens 78 patients. By subtype, 54 cases were ulcerated, 3 2 5 11 peristomal, unclassifiable. The double labeled for MPO citrullinated histone H3. Immunofluorescent images indicated that formed shallow dermis within epidermis bullous compared ulcerative PG. Although other now under investigation, these data suggest may determine
منابع مشابه
Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum
BACKGROUND Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is highly associated with inflammatory bowel disease (IBD). Certain PG patients with no systemic disorders have been diagnosed with idiopathic PG. This study sought to clarify the difference between PG with IBD and idiopathic PG based on clinical features, laboratory tests, and medications. METHODS Twelve patients wit...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.353